{"componentChunkName":"component---src-templates-html-tsx","path":"/systems/05-renal---urinary---fluids---electrolytes/4--syndromes---diseases/pckd---polycystic-kidney-disease","result":{"pageContext":{"slug":"/systems/05-renal---urinary---fluids---electrolytes/4--syndromes---diseases/pckd---polycystic-kidney-disease","crumbs":[{"slug":"/systems","display":"Systems"},{"slug":"/systems/05-renal---urinary---fluids---electrolytes","display":"05 Renal Urinary Fluids Electrolytes"},{"slug":"/systems/05-renal---urinary---fluids---electrolytes/4--syndromes---diseases","display":"4 Syndromes Diseases"}],"name":"PCKD | Polycystic Kidney Disease","html":"\n\n\n\n\n\n\n

Polycystic Kidney Disease

Last modified: 16 August 2022, 1:29:59 PM AEST

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Genetic\n
- AD = ADPKD\n
  - 10% CKD / ESRF
  - PKD1 gene = 85%\n
    - protein involved in cell regulation, and iCa transport
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  - PKD2 gene\n
    - voltage-linked cation channels
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  - PKD3
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- AR = ARPKD\n
  - less common
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Pathophysiology1 / 3

renal tubules become structurally abnormal
development of multiple renal cysts = non-functioning tubules
cyst formation\n
- linked to abnormal cilia-mediated signalling
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Complications / Issues2 / 3

C = Cardiovascular\n
- Aortic root aneurysms
- HTN from RAAS activation
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D = Neurological\n
- Cerebral aneurysms
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F = Renal\n
- Renal failure
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Anaesthetic considerations3 / 3

Pre-op
Intra-op
Post-op

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