• consider placing external pads for pacing, esp if prone (difficult to place emergently)

• SVT
• nuclear stress test

• asthma

• 100-300 mcg/kg
  • adult = 6-12 mg
• cardiac standstill in NSX
  • onset 10-20 sec
  • 24 mg = 4 ampoules

(molecular structure)

• adenine attached to ribose
• via beta-N9-glycosidic bond

(formulation)

• 1 vial = 6 mg

Mechanism of action

(molecular effects)

(therapeutic effects + indications / side effects + contraindications)

1:CVS

• transient heart block at AV node
  • A1-receptor
  • inhibition adenylyl cyclase, ⬇cAMP, cell hyperpolarisation by ⬆K efflux, subsequent inhibition of Ca current
• vasoD of normal segments of arteries
  • exaggerates the difference between normal and abnormal segments
  • reduces BQ distal to occlusion, causing ischaemia
  • coronary steal phenomenon
    • vasoD of healthy coronary As
    • diseased coronaries are already maximally dilated
    • this causes redistribution of BQ to non-ischaemic areas, causing myocardial ischaemia

2:RS

• bronchospasm
  • CIN = asthma

3:NS

4:GIT

5:Renal

6:Endo

7:Haem

8:MSk

9:Reprod

10:Other

• tachyphylaxis

• onset =
• offset =

Absorption

• Bioavailability

Distribution

Metabolism

• main organ of metabolism =
  • cellular uptake
• active metabolites =
• et1/2 =
  • less than 10 seconds

Excretion

Adenosine to facilitate the clipping of cerebral aneurysms: literature review, SVN 2017