Amiodarone
Last modified: 04 March 2021, 1:16:47 PM AEDT
Dosage1 / 5
- 200 mg tablet = 6 mg iodine = 20x daily dose
Chemistry2 / 5
(molecular structure)
Pharmaceutics3 / 5
(formulation)
Mechanism of action
(molecular effects)
Pharmacodynamics4 / 5
(therapeutic effects + indications / side effects + contraindications)
1:CVS
2:RS
3:NS
4:GIT
5:Renal
6:Endo
- inhibit T4 to T3 conversion
- block T3 nuclear receptor binding
- thyroid dysfunction in 2-30%
- clinical thyroid disease = 3.7%
7:Haem
8:MSk
9:Reprod
10:Other
Pharmacokinetics5 / 5
- onset =
- offset =
Absorption
- Bioavailability
Distribution
Metabolism
- main organ of metabolism =
- active metabolites =
- et1/2 = 100 days = LONG