Metaraminol
Last modified: 28 October 2021, 9:09:10 PM AEDT
Dosage1 / 5
- 5-10 mcg/kg
- eg. 5 kg child = 25-50 mcg
- pre-drawn paeds = 50 mcg/mL = 1 mL
- eg. 100 kg adult = 500-1000 mcg = 0.5-1 mg, but in practice 0.5 mg is given
Chemistry2 / 5
(molecular structure)
Pharmaceutics3 / 5
(formulation)
Mechanism of action
(molecular effects)
- sympathomimetic
- direct
- agonist at adrenergic receptors
- mainly alpha-1 agonist
- some beta-1 agonist
- indirect
- NAd reuptake inhibitor
- ⬆release of endogenous NAd
- may become depleted, contributing to tachyphylaxis
Pharmacodynamics4 / 5
(therapeutic effects + indications / side effects + contraindications)
1:CVS
- ⬆SVR
- ⬆contractility
- reflex bradycardia
2:RS
3:NS
4:GIT
5:Renal
6:Endo
7:Reprod
8:Haem
9:MSk
10:Other
Pharmacokinetics5 / 5
- onset =
- offset =
Absorption
- Bioavailability
Distribution
Metabolism
- main organ of metabolism =
- active metabolites =
- et1/2 =