Prostacyclin
Last modified: 09 February 2021, 8:38:03 AM AEDT
- epoprostenol
Gems1 / 8
- continuous delivery via PICC
- brief interruption can lead to profound rises in PVR and death
Indications2 / 8
- rescue therapy for same conditions as iNO
- pulmonary HTN
- limb ischaemia
Dosage3 / 8
- IV infusion
- 1 ng/kg/min
- increase by 2 ng/kg/min until balance between efficacy and tolerability
- max = 25 mg/kg/min
Chemistry4 / 8
(molecular structure)
- eicosanoid lipid
- synethetic analogues
- iloprost = inhaled
Pharmaceutics5 / 8
(formulation)
Mechanism of action
(molecular effects)
Pharmacodynamics6 / 8
(therapeutic effects + indications / side effects + contraindications)
1:CVS
- vasoD
- flushing
- headache
- hypotension
2:RS
3:NS
4:GIT
5:Renal
6:Endo
7:Reprod
8:Haem
- anti-thrombotic = inhibits platelet activation
- anti-inflammatory
- anti-mitogenic
- anti-proliferative
9:MSk
10:Other
Pharmacokinetics7 / 8
- onset =
- offset =
Absorption
- Bioavailability
Distribution
Metabolism
- main organ of metabolism =
- active metabolites =
- et1/2 = seconds