Dantrolene
Last modified: 24 July 2022, 6:35:47 PM AEST
Dosage1 / 6
- MH
- initial bolus = 2.5 mg/kg
- repeat boluses = 1 mg/kg Q10-15 min
- max dose = 10 mg/kg
Chemistry2 / 6
(molecular structure)
Pharmaceutics3 / 6
(formulation)
Mechanism of action
(molecular effects)
Pharmacodynamics4 / 6
(therapeutic effects + indications / side effects + contraindications)
1:CVS
- Thrombophlebitis
- From continuous infusion = boluses are preferred
- Due to high osmolarity of solution
2:RS
3:NS
4:GIT
5:Renal
6:Endo
7:Haem
8:MSk
9:Reprod
10:Other
Pharmacokinetics5 / 6
- onset =
- offset =
Absorption
- Bioavailability
Distribution
Metabolism
- main organ of metabolism =
- active metabolites =
- et1/2 =