Dantrolene

Last modified: 24 July 2022, 6:35:47 PM AEST
Dosage1 / 6
  • MH
    • initial bolus = 2.5 mg/kg
    • repeat boluses = 1 mg/kg Q10-15 min
    • max dose = 10 mg/kg

Chemistry2 / 6

(molecular structure)


Pharmaceutics3 / 6

(formulation)


Mechanism of action

(molecular effects)


Pharmacodynamics4 / 6

(therapeutic effects + indications / side effects + contraindications)

1:CVS

  • Thrombophlebitis
    • From continuous infusion = boluses are preferred
    • Due to high osmolarity of solution

2:RS

3:NS

4:GIT

5:Renal

6:Endo

7:Haem

8:MSk

9:Reprod

10:Other


Pharmacokinetics5 / 6
  • onset =
  • offset =

Absorption

  • Bioavailability

Distribution

Metabolism

  • main organ of metabolism =
  • active metabolites =
  • et1/2 =

Excretion


Links6 / 6

MH AAGBI 2020