Context-Sensitive Half Time
Last modified: 26 February 2021, 3:49:20 PM AEDT
Gems1 / 3
- the time required for the plasma concentration of an INFUSED drug to fall to half of the concentration when the infusion is STOPPED
- the "context" = DURATION of infusion
- provides useful guidance for the expected INCREASE in time required to eliminate a drug, as the length of the infusion increases
Propofol2 / 3
- even for infusions of 480 minutes, the plasma propofol concentration decreases by 50% within 5 minutes of stopping the infusion
- for steady state (ie. infinite infusions), the propofol concentrations decrease by 50% within 10 minutes of stopping the infusion