Context-Sensitive Half Time

Last modified: 26 February 2021, 3:49:20 PM AEDT
Gems1 / 3
  • the time required for the plasma concentration of an INFUSED drug to fall to half of the concentration when the infusion is STOPPED
  • the "context" = DURATION of infusion
  • provides useful guidance for the expected INCREASE in time required to eliminate a drug, as the length of the infusion increases
Propofol2 / 3
  • even for infusions of 480 minutes, the plasma propofol concentration decreases by 50% within 5 minutes of stopping the infusion
  • for steady state (ie. infinite infusions), the propofol concentrations decrease by 50% within 10 minutes of stopping the infusion
References3 / 3

https://derangedphysiology.com/main/cicm-primary-exam/required-reading/pharmacokinetics/Chapter%20323/context-sensitive-half-time